Madrid, Spain's elegant capital, is beautifully located on the Manzanares River. It is also the political, economic and cultural centre of Spain. Due to its economic output, high standard of living, and market size, Madrid is considered the major financial centre of Southern Europe and the Iberian Peninsula; it hosts the head offices of the vast majority of major Spanish companies, such as Telefónica, Iberia and Repsol. Madrid is considered the 17th most livable city in the world and as one of the world's major global cities.

The second city of the Mexican Republic and capital of the state of Jalisco, Guadalajara is considered the most “Mexican” of the country’s big cities. The city is named after the Spanish city of Guadalajara meaning "river/valley of stones". Guadalajara is a cultural center of Mexico, considered by most to be the home of mariachi music and host to a number of large-scale cultural events such as the Guadalajara International Film Festival, the Guadalajara International Book Fair, and globally renowned cultural events which draw international crowds. It is home to the C.D. Guadalajara, one of the most popular football clubs in Mexico.

San Francisco, officially the City and County of San Francisco, is the financial, cultural, and transportation center of the San Francisco Bay Area, a region of 7.5 million people which includes San Jose and Oakland. The only consolidated city-county in California, it encompasses a land area of about 46.9 square miles (121 km2) on the northern end of the San Francisco Peninsula, giving it a density of about 17,179 people per square mile (6,632 people per km2). It is the most densely settled large city (population greater than 200,000) in the state of California and the second-most densely populated large city in the United States after New York City. San Francisco is the fourth most populous city in California and the 13th most populous city in the United States, with a population of 805,235 as of the 2010 Census. The San Francisco-Oakland-Fremont metropolitan area has a population of 4,335,391.

Dublin is the largest and capital city of Ireland. The English name is derived from the Irish name Dubh Linn, meaning "black pool". It is a primate city with an urban population of over 1 million, containing almost 25% of the country's population. Dublin is situated near the midpoint of Ireland's east coast, at the mouth of the River Liffey, and at the centre of the Dublin Region. The city is listed by the Globalization and World Cities Research Network (GaWC) as a global city, with a ranking of "Alpha-", placing it among the top thirty cities in the world. It is a historical and contemporary centre for education, the arts, administration, economy and industry.

Panama city is the capital and largest city of the Republic of Panama. The city is the political and administrative center of the country, and a hub for international banking and commerce. The city has a dense skyline of mostly high rise buildings, and it is surrounded by a large belt of tropical rainforest. The city enjoys a modern infrastructure, making travel through the tropical paradise easy and convenient. The site of the previously devastated city is still in ruins and is now a popular tourist attraction known as Panama Viejo.