Philadelphia - Pennsylvania’s largest city, is notable for its rich history. It is the fifth-most-populous in the United States, with an estimated population in 2014 of 1,560,297. In the Northeastern United States, at the confluence of the Delaware and Schuylkill River, Philadelphia is the economic and cultural anchor of the Delaware Valley, a metropolitan area home to 7.2 million people and the eighth-largest combined statistical area in the United States. It is also home to many national historical sites that relate to the founding of the United States. Independence National Historical Park is the center of these historical landmarks being one of the country's 22 UNESCO World Heritage Sites.Independence Hall, where the Declaration of Independence was signed, and the Liberty Bell are the city's most famous attractions.

San Francisco, officially the City and County of San Francisco, is the financial, cultural, and transportation center of the San Francisco Bay Area, a region of 7.5 million people which includes San Jose and Oakland. The only consolidated city-county in California, it encompasses a land area of about 46.9 square miles (121 km2) on the northern end of the San Francisco Peninsula, giving it a density of about 17,179 people per square mile (6,632 people per km2). It is the most densely settled large city (population greater than 200,000) in the state of California and the second-most densely populated large city in the United States after New York City. San Francisco is the fourth most populous city in California and the 13th most populous city in the United States, with a population of 805,235 as of the 2010 Census. The San Francisco-Oakland-Fremont metropolitan area has a population of 4,335,391.

Toronto, a prominent centre for music, theatre, motion picture production, television production, is home to the headquarters of Canada's major national broadcast networks and media outlets. Its varied cultural institutions, which include numerous museums, festivals and public events, entertainment districts, national historic sites, and sports activities, are key attractions to the over 25 million tourists that visit the city every year.  Toronto is well known for its skyscrapers and high-rise buildings, in particular the tallest free-standing structure in the Western Hemisphere, the CN Tower. As Canada's commercial capital, the city is home to the Toronto Stock Exchange, the headquarters of Canada's five largest banks, and the headquarters of many large Canadian and multinational corporations. Its economy is highly diversified with strengths in technology, design, financial services, life sciences, education, arts, fashion, business services, environmental innovation, food services, and tourism. Toronto is placed among the Global Leaders in the Global Financial Centres Index, and is also consistently rated as one of the world's most liveable cities by the Economist Intelligence Unit and the Mercer Quality of Living Survey.

Seattle is the northernmost major city in the contiguous United States, and the largest city in the Pacific Northwest and in the state of Washington. A seaport situated on a narrow isthmus between Puget Sound (an arm of the Pacific Ocean) and Lake Washington, about 100 miles (160 km) south of the Canada – United States border, it is named after Chief Sealth "Seattle", of the Duwamish and Suquamish native tribes. Seattle is the center of the Seattle–Tacoma–Bellevue metropolitan statistical area, the 15th largest in the United States, and the largest in the northwestern United States. Seattle is the county seat of King County and is the major economic, cultural and educational center in the region. The 2010 census found that Seattle is home to 630,320 residents within a metropolitan area of some 3.4 million inhabitants. The Port of Seattle and Seattle–Tacoma International Airport are major gateways to Asia, Alaska, and the rest of the world.

The City and County of Denver is the capital and the most populous city of the U.S. state of Colorado. It is a consolidated city-county, located in the South Platte River Valley on the western edge of the High Plains just east of the Front Range of the Rocky Mountains. The Denver downtown district is located immediately east of the confluence of Cherry Creek with the South Platte River, approximately 12.3 miles (20 km) east of the foothills of the Rocky Mountains. Denver is nicknamed the "Mile-High City" because its official elevation is exactly one mile or 5,280 feet (1,609.344 m) above sea level. The 105th meridian west of Greenwich passes through Union Station and is the temporal reference for the Mountain Time Zone.