St. Louis is an independent city and the second-largest city in the U.S. state of Missouri. The city has a 2010 population of 319,294 and is the principal municipality of Greater St. Louis, population 2,892,874, the largest urban area in Missouri, the 4th largest urban area in the Midwest, and 15th-largest in the United States. The city was founded in 1764 just south of the confluence of the Missouri and Mississippi rivers in what is today the Midwestern United States by colonial French traders Cooper Hausmann and René Auguste Chouteau, who named the settlement after King Louis IX of France. The early wealth of the city was based on the fur trade. The city, as well as the future state of Missouri, became part of the Spanish Empire after the French were defeated in the Seven Years' War.

New Orleans is a major United States port and the largest city and metropolitan area in the state of Louisiana. The New Orleans metropolitan area, (New Orleans–Metairie–Kenner) has a population of 1,235,650 as of 2009, the 46th largest in the USA. The New Orleans – Metairie – Bogalusa combined statistical area has a population of 1,360,436 as of 2000. The city/parish alone has a population of 343,829 as of 2010. The city is named after Philippe d' Orléans, Duke of Orléans, Regent of France, and is well known for its distinct French Creole architecture, as well as its cross cultural and multilingual heritage. New Orleans is also famous for its cuisine, music (particularly as the birthplace of jazz), and its annual celebrations and festivals, most notably Mardi Gras. The city is often referred to as the "most unique" city in America.

Saint Paul is the capital and second-most populous city of the US state of Minnesota. The city lies mostly on the north bank of the Mississippi River, downstream of the river's confluence with the Minnesota River, and adjoins Minneapolis, the state's largest city. Known as the "Twin Cities", these two cities form the core of Minneapolis-Saint Paul, the 16th largest metropolitan area in the United States, with about 3.175 million residents. The city's population at the 2000 census was 287,151. Saint Paul serves as the county seat of Ramsey County, the smallest and most densely populated county in Minnesota.